The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility.

While seemingly less profound, the difference between the distributions of correlation of intra and extra module genes is highly significant (p-value < 5x10 -324 , Kolmogorov–Smirnov test for equal distributions) with a tendency of the genes belonging to the same module to have higher correlations (p-value < 5x10 -324 , Wilcoxon sum rank test).

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