Recurrent somatic mutations as predictors of immunotherapy response.

We then stratified the analysis of TMB across the eligible tumor types and found significant associations with ICB response in melanoma and NSCLC (melanoma: 1.5-fold, Welch’s two-tailed t test p = 2.0 × 10 −5 ; NSCLC: 2.5-fold, p = 0.003) and a positive trend amongst bladder and head and neck tumors (bladder: 1.9-fold, Welch’s two-tailed t test p = 0.08; head and neck: 1.1-fold, p = 0.94) (Fig. 1e ).

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