Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants.

The damaging variant in ALDH2 , rs671, is much less frequent in cases than controls for both phenotypes but is so rare in this largely European sample that it only produces modestly significant results.

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This shows that rs1229984, the gain of function variant in ADH1B , produces highly significant evidence for a protective effect for both phenotypes but that the other tested variants in ADH1B and ADH1C are not significantly associated with either phenotype.

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