Topoisomerase VI participates in an insulator-like function that prevents H3K9me2 spreading.

In contrast, a clear increase was observed within S-EIs of caa39 , which was highly significant all along S-EIs (Mann–Whitney U test, Benjamini-corrected P < 0.01), suggesting that Topo VI prevents H3K9me2 spreading across natural boundaries ( Fig. 4 B ).

also in 132,142 other papers