Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA.

Front Toxicol · 2022 · PMC9271854 · PMID 35832492

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Altered expression of genes within PPARα-specific signaling and lipid metabolism pathways (e.g., peroxisomal and mitochondrial fatty acid β-oxidation) resulted in highly significant enrichment of these gene sets, demonstrating that transcriptomic responses to HFPO-DA are mediated through PPARα.

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