In the Cochrane meta-analysis 16 although a tendency toward statistical significance was seen in OS for the curative intent studies, the included trials, as stated earlier, had clinical heterogeneity since they grouped the results of different oral formulations into a single category.
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Oral Tegafur-Uracil Combination plus Leucovorin versus Other Fluoropyrimidine Agents in Colorectal Cancer: A Systematic Review and Meta-Analysis.
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