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Ischemic Heart Disease and Chronic Obstructive Pulmonary Disease Hospitalizations in Japan Before and After the Introduction of a Heated Tobacco Product.

Front Public Health · 2022 · PMC9275563 · PMID 35836991

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a decreasing trendno p-value reported
Further, applying the later breakpoint for COPD exacerbations resulted in a decreasing trend following HTP introduction, contrary to the upward trend observed in the main analysis.

also in 47,180 other papers

an increasing trendno p-value reported
In all four models, pre-HTP COPD hospitalization numbers showed an increasing trend.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.