Integrative analysis of genomic and transcriptomic alterations of <i>AGR2</i> and <i>AGR3</i> in cancer.

Another way of analysing relationships between CNV and expression was to consider chromosome 7p losses in these cancer types; there were only three shallow 7p deletions in COADREAD out of 492 samples, not allowing comparisons, but in BRCA (66 samples with 7p loss out of 850 samples), there was significantly lower AGR2 and AGR3 expressions when chromosome 7p was lost ( p = 4.72 × 10 −13 and 2.7 × 10 −9 , respectively); in LUAD and OVCA, barely significant lower expression values were noticed, and no significant results were obtained in LUSC ( figure 5 ).

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It is interesting to note that the expressions of genes encoding the transcription factors of EMT are negatively correlated with those encoding AGR2 and AGR3 : ZEB1 / 2 with a very high significance, TWIST1 / 2 and SNAI1 / 2 with lower p -values, but still highly significant.

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The expression of the genes encoding the transcription factors involved in EMT ( SNAI , ZEB and TWIST families) were often negatively correlated with AGR2 expression, but this generally remains slightly below the level of significance we have chosen for 1% risk.

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