A novel 5-Fluorocuracil multiple-nanoemulsion used for the enhancement of oral bioavailability in the treatment of colorectal cancer.

Saudi J Biol Sci · 2022 · PMC9280251 · PMID 35844373

Europe PMC DOI

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0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

extremely significantp < 0.001actually significant

The enhanced C max with AUC 0-8h with opt-5-FU-MNE was shown extremely significant (p < 0.001) in wistar rat’s plasma in the comparison of oral and i.v. treated group of 5-FU-S by PK-observations.

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highly significantp<0.05actually significant

5-FU-release ( in vitro ) from 5-FU-MNEs (w/o/w, MNE1, MNE5, and MNE9 SNEDDS) were showed highly significant (p<0.05) as compared to other 5-FU-MNEs (w/o/w, SNEDDS) ( Fig. 5 A).

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