IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases.

SDS-PAGE analysis of IL-36 family cytokines incubated for 2h at 37°C in the presence of the panel of allergen extracts revealed patterns of proteolysis that broadly correlated with the outcome of the bioactivity assays ( Figure 2D ), although it should be noted that trace amounts of proteolysis can often be sufficient to produce highly significant amounts of active cytokine.

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