Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database.

In terms of the infection site, multiple infections showed the highest gross medical costs with an increasing trend (rate = + $63.6 million/year, p < 0.0001) followed by respiratory infection (rate = + $65.0 million/year, p = 0.002).

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Patients with life-sustaining interventions, including mechanical ventilation, vasopressor therapy, and renal replacement therapy, displayed a decreasing trend of the effective cost per survivor during the years.

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