Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork.

Since we found the paxillin and phospho paxillin to increase significantly, we calculated their pairwise ratio and found that the mean ratio was greater than 1 (1.26) but did not achieve significance (Figure 3h ).

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We observed a decreasing trend (Figure 1e ) in clusterin mRNA expression whereas a significant decrease in protein levels in the TM cells subjected to CMS.

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