Tail bleeding experiments revealed no significant differences in bleeding time in either PF4cre-CypD fl/fl or -TMEM16F fl/fl animals, with TMEM16F-deficient mice exhibiting a nonsignificant trend toward longer time to hemostasis (supplemental Figure 4G-H).
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Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.
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