Copy number variation characterization and possible candidate genes in miscarriage and stillbirth by next-generation sequencing analysis.

The rates of chromosomal abnormality in these groups were 59.13% (285/482), 21.28% (30/141) and 19.44% (7/36), respectively, showing a decreasing trend with respect to the increasing gestational age of the fetuses (χ 2 = 75.741, p < 0.001).

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2 The incidence of miscarriage is about 15–20% and there is an increasing trend year by year. 3 The incidence of stillbirth is about 0.5–0.6%. 4 The causes of miscarriage and stillbirth including environmental factors, endocrine diseases, immune diseases and genetic factors.

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