Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

CPT Pharmacometrics Syst Pharmacol · 2022 · PMC9286715 · PMID 35445542

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a slight trendno p-value reported

However, a slight trend toward underprediction of the C max ratio was observed for the 20 CYP2C9 clinical studies that were evaluated in the qualification with a bias of 0.88.

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