Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection.

Front Cell Infect Microbiol · 2022 · PMC9289478 · PMID 35860381

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may be significantno p-value reported

We used both poly:IC and LPS to highlight that regardless of signaling through TLR3-TRIF or TLR4-TRIF and MyD88, the effects of CYP450 lipid-PPARα axis acts further downstream of the signaling cascade which may be significant due to the difference in PAMPs detected in multi-pathogenic interactions with the host immunity in superinfection.

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