27 , 28 With random assignment of exposure target, the association between AUC and BPAR was highly significant, whilst that between MMF dose and BPAR was not. 28 The second TCI trial, APOMYGRE, compared MMF TCI with fixed dosing. 29 Again TCI was successful in controlling MPA exposure 29 and led to a substantial reduction in BPAR in the TCI compared with the fixed dose arm (7.7% vs 24.6%). 2
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