miRNA 130 was evident as highly significant and has been documented to promote vasoconstriction in pulmonary hypertension via deregulation of vasoactive mediators such as endothelin-1 [ 43 ]. miRNAs play important roles in mediating endotoxin tolerance at placental tissue via feedback loops at TLR receptors, and miRNAs packaged in extracellular vesicles translocate to remote sites including trophoblasts and maternal tissues effecting proinflammatory mechanisms [ 33 ].
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Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association.
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