Anti-cancer therapy is associated with long-term epigenomic changes in childhood cancer survivors.

Both sets of sites exhibited highly significant overlap with the CpG sites identified in this study, especially for those associated with drug combinations (36/224, 16.1% overlapping, p < 1 × 10 −50 (Fisher exact test), with all differences at matching CpG sites altered in the same direction), further suggesting that these methylation changes are consistent consequences of exposure to highly toxic anti-cancer therapies.

also in 127,188 other papers

Cell type distribution was similar before and after exposure to cancer therapy, although there was a borderline significant drop in B-lymphocytes seen in both haematological and solid tumour patients (Supplementary Table 2 ).

also in 10,988 other papers