Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomised, controlled trial.

Addiction · 2022 · PMC9302677 · PMID 35137493

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borderline significantno p-value reported

However, in the safety set, a post hoc analysis revealed a borderline significant estimated risk difference of 6.8% (95% CI, 0.2%–13%), with a lower risk of withdrawal in the IN group.

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