Medial Prefrontal Cortex Glutamate Is Reduced in Schizophrenia and Moderated by Measurement Quality: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.

Biol Psychiatry · 2021 · PMC9303057 · PMID 34344534

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highly significantno p-value reported

DISCUSSION In this largest meta-analysis yet, to our knowledge, of brain glutamate measured separately from glutamine using proton MRS in a psychiatric disorder, we observed a small but highly significant reduction in mPFC glutamate in schizophrenia.

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