Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton's Tyrosine Kinase.

However, unlike the previously reported effects of other Btk inhibitors on autoantibody production, this study using NZBW/F1 mice did not demonstrate significant inhibition of total immunoglobulins and autoantibodies, though a decreasing trend in IgG anti-dsDNA levels were noted following BTKB66 treatment.

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