highly significantP < 0.0001
This increase was especially pronounced for moribund individuals and during the “High & Prolonged 1” trial (Supporting Information Figure S2 ), and is supported by the highly significant differences in CIE b * values between trials ( F = 38.17, df = 6, P < 0.0001) and between monitoring periods ( F = 6.21, df = 4, P < 0.0001).