Methods for culturing adult CNS neurons reveal a CNS conditioning effect.

We found a highly significant and substantial central conditioning effect: animals that received a spinal cord injury 24 h before preparation of motor cortex cultures exhibited a 4-fold increase in total neurite outgrowth compared with cortical neurons from controls that did not have a preceding spinal cord lesion (overall ANOVA p < 0.0001; post hoc Fischer’s comparing intact to 24 h, p < 0.0001; Figure 4 F).

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