highly significantp -value < 10 −192
In addition to their propensity to be longer, proteins from the aggregation group also exhibited a higher relative frequency of methionines than random or dispersion proteins ( Figure 4 B), leading to a highly significant larger number of methionine residues per protein within the aggregation group, when compared to the dispersion ( p -value < 10 −192 , pairwise Wilcoxon rank sum test) or the random category ( p -value = 4 × 10 −192 , pairwise Wilcoxon rank sum test) ( Figure 4 C).