extremely significantp -value < 0.0001
According to GraphPad Prism 7 software, * a p -value 0.01–0.05 was considered statistically significant, ** a p -value 0.001–0.01 very significant and *** a p -value 0.0001–0.001 extremely significant, while **** a p -value < 0.0001 was very extremely significant. 3.