In-Silico Analysis of pH-Dependent Liquid-Liquid Phase Separation in Intrinsically Disordered Proteins.

Biomolecules · 2022 · PMC9313257 · PMID 35883530

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highly significantp < 1 −10actually significant

When plotting the solubility and disorder scores at neutral pH (pH = 7.0), a highly significant linear correlation was observed between these two variables (R 2 = 0.90, p < 1 −10 ) ( Figure 3 ), suggesting that solubility and disorder are intimately ligated in this dataset.

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