Some relevant conclusions can be distilled from our results: As far as the substrate is regarded, and with the particular exception of the neopentyl group, the steric compression undergone by the electrophile during the initial stages of the reaction shows an increasing trend with the bulkiness of the substrate, in agreement with the trends followed by the activation barriers.
← all excerpts
A real space picture of the role of steric effects in S<sub>N</sub> 2 reactions.
1
—
—