Natural and Induced Tolerance to Hymenoptera Venom: A Single Mechanism?

Regarding sIgG4 values to allergenic components, an increasing trend is observed at T2 with respect to T0: rApi m 1 ( p < 0.001, t me = 3.78), rApi m 2 ( p = 0.142, t me = 1.49), rApi m 3 ( p = 0.108, t me = 1.63), Api m 4 ( p < 0.001, t me = 3.64), rApi m 5 ( p = 0.014, t me = 2.52), and rApi m 10 ( p = 0.002, t me = 3.27), which is maintained at T3: rApi m 1 ( p = 0.003, t me = 3.08), rApi m 2 ( p = 0.176, t me = 1.37), rApi m 3 ( p = 0.743, t me = 0.33), Api m 4 ( p = 0.743, t me = 0.33), rApi m 5 ( p = 0.075, t me = 1.81), and rApi m 10 ( p = 0.715, t me = 0.37).

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As in other previous works on VIT [ 37 , 38 , 39 ], basophil activation decreased throughout treatment, with the differences being extremely significant at T3 when the differences with TG were diluted, becoming virtually identical.

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In parallel, there was a sustained increase in sIgG4 to all molecular components, which was highly significant in the case of rApi m 1.

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