Changes in key recruitment performance metrics from 2008-2019 in industry-sponsored phase III clinical trials registered at ClinicalTrials.gov.

PLoS One · 2022 · PMC9321424 · PMID 35881593

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an increasing trendno p-value reported

et al found an increasing trend in clinical trial protocol complexity across phase I, II and III clinical trials based on 9373 protocols of which 76% were protocols provided by large companies [ 3 ].

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