Phosphodiesterase 10A (PDE10A): Regulator of Dopamine Agonist-Induced Gene Expression in the Striatum.

Cells · 2022 · PMC9324899 · PMID 35883657

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Our results demonstrate a highly significant positive correlation between local PDE10A expression and the PDE10A inhibitor-induced expression of gene markers in both D1- and D2-MSNs, and a similar positive relationship between the basal PDE10A levels and gene induction by dopamine depletion and L-DOPA treatment in a Parkinson’s disease model, as well as by psychostimulants (cocaine, methylphenidate) in the intact striatum. 2.

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