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Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies.

Neoplasia · 2022 · PMC9326335 · PMID 35901621

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an increasing trendno p-value reported
Despite an overall decline in over the last two decades, it is known that individuals younger than 50 years [2] have shown an increasing trend in incidence, which is likely to hold in the near future.

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