Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

Moreover, this study not only evaluated the independent effects of METS-IR and the risk of kidney stone development, but also examined the dose–response relationship between the two factors and derived a threshold effect for METS-IR of 59.8314.In comparison to the left side of the inflection point, when METS-IR was at 59.8314, there was an increasing trend in kidney stone occurrence with increasing METS-IR (OR =1.0238, 95% CI: 1.0178-1.0299); however, when METS-IR was at 59.8314, the trend gradually plateaued compared to the right side of the inflection point (OR =1.0015, 95% CI. 0.9957-1.0073).The factors included in this study were stratified by sex, age, hypertension, and diabetes status, while the interaction test p-values were not statistically significant, indicating that this association was independent of age, hypertension, and diabetes, suggesting that it could be applied to all types of populations.

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