Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits.

Interestingly, MuRF1 expression was significantly upregulated only in female Compound-Het gastrocnemius muscle when comparing MuRF1 protein levels between sexes with Sidak’s multiple comparison as post hoc test, although a highly significant genotype effect existed on two-way ANOVA using genotype and sex as factors ( Supplemental Figure S1 ).

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