"In Litero" Screening: Retrospective Evaluation of Clinical Evidence to Establish a Reference List of Human Chemical Respiratory Sensitizers.

A slight trend favoring a higher incidence of reports from industrial settings is observed, which may be reflective of the historical exposures to classical industrial respiratory sensitizers such as anhydrides and isocyanates. 3.2 Protein Binding Profiles of Clinical Respiratory Sensitizers In order to explore what our dataset of respiratory sensitizers may show about the molecular initiating event of respiratory sensitizers, we used the QSAR Toolbox (v. 4.4.1, OECD) to profile the protein binding mechanism(s) of each of the 354 chemicals within our investigation set ( Figure 6 ).

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