A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.

Mol Cancer · 2022 · PMC9336057 · PMID 35906694

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highly significantno p-value reported

When AC220 (10 mg/Kg) was used in combination with the BGJ398 FGFR1 inhibitor (30 mg/Kg) there was not only a highly significant increase in survival compared with AC220 treatment alone but also a significant increase in survival compared with BGJ398 treatment alone (Fig. 7 K).

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