Application of fluoride disturbs plaque microecology and promotes remineralization of enamel initial caries.

The results showed that a significant increasing trend of the constituent ratio of code 0 and a decreasing trend of code 1 were evaluated after fluoride application at almost all surface sites, which demonstrated that fluoride could significantly inhibit enamel demineralization and promote the remineralization of early demineralized caries enamel over the short term.

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The species richness and diversity appear to be an increasing trend at 3 days after fluoride application, which suggests that dental plaque microecology was more diversified after fluoride application.

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