LRRK2 was identified as a hub gene with the highest degree of betweenness centrality; its physical interaction enrichment score was 1.28, which was highly significant.
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The Protein-Protein Interaction Network of Hereditary Parkinsonism Genes Is a Hierarchical Scale-Free Network.
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On applying more stringent data curation criteria (quality score ≥3), the results remained the same except for PD GWAS proteins (before excluding PARK and non-PARK proteins), which were marginally significant ( Supplementary Table 6 , only online).