The results were shown in Figure 5A–D 3.6 Effect of variations in mtDNA copy number on mitochondrial respiratory chain complexes In HEK 293T cells transfected with knockdown TFAM plasmid (sh‐TFAM), the activity of mitochondrial respiratory chain complex I and II decreased significantly ( p < 0.05); while after transfection of HEK 293T cells with overexpressed TFAM plasmid (OE‐TFAM), the activity of the complex II was remarkably increased ( p < 0.05), and the activity of the complex I showed an increasing trend which yet had no statistical difference.
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Decrease of MtDNA copy number affects mitochondrial function and involves in the pathological consequences of ischaemic stroke.
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