Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.

Discrimination followed the order IL‐2 > IL‐13 > IFN‐γ with, however, only subtle differences in the respective highly significant AUC (0.9310, 0.8994, 0.8316) values (all p < .0001; Figure S7 A), which was similar to the results obtained with gradient‐purified PBMC with regard to IL‐13 and IFN‐γ while IL‐2 levels were clearly lower and less discriminatory after 6 days (Figure S4 A).

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