(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H₂O₂ Through Activation of Nrf2 Pathway.

GSH level showed a decreasing trend in cells exposed to 400 μm H 2 O 2 (4.54 ± 1.58 μmol/gprot; p < 0.01) relative to Control (20.41 ± 0.75 μmol/gprot), whereas treatment with BFB (15 and 30 μm) remarkably mitigated GSH levels within 400 μm H 2 O 2 -treated cells (12.78 ± 0.34, 17.14 ± 1.3 μmol/gprot respectively, p < 0.05, p < 0.01). 3.3 BFB Showed Protection on H 2 O 2 -Mediated Apoptosis of PC12 Cells and Ameliorated Mitochondrial Dysfunction To quantitatively demonstrate BFB’s impact on H 2 O 2 -mediated apoptosis, FCM was conducted by Annexin V/PI staining.

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