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A Novel Berberine-Glycyrrhizic Acid Complex Formulation Enhanced the Prevention Effect to Doxorubicin-Induced Cardiotoxicity by Pharmacokinetic Modulation of Berberine in Rats.

Front Pharmacol · 2022 · PMC9353711 · PMID 35935857

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might not be significantno p-value reported
Thus, we considered that the BBR-GL complex in oral administration could improve the absorption and bioavailability of BBR while the metabolism of BBR might not be significant inference in vivo . 3.5 Berberine–Glycyrrhizic Acid Complex Enhances the Protective Effect of Berberine and Glycyrrhizic Acid Against Acute Doxorubicin-Induced Cardiac Injury We first explored the possible toxicity or side effects of BBR-GL by hemolytic parameters and histopathological examinations.

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