Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.

Front Immunol · 2022 · PMC9354126 · PMID 35935988

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highly significantno p-value reported

These results revealed a highly significant and consistent pattern of enhanced selectivity for EGFR-high targets (SKOV3 or U87vIII) over EGFR-low tumor targets (MCF7) or healthy-donor HDF cells with hinge-truncated EGFR-sdCARs ( Figures 5G, H ).

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