In particular, the deletion of genes encoding an EAL domain alone or in combination with a GGDEF domain resulted in minimal changes to overall c-di-GMP concentration, but highly significant differences in biofilm architecture ( Figures 3 , 4 ).
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Phenotypic and integrated analysis of a comprehensive <i>Pseudomonas aeruginosa</i> PAO1 library of mutants lacking cyclic-di-GMP-related genes.
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