Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome.

Front Cell Neurosci · 2022 · PMC9355602 · PMID 35936502

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highly significantno p-value reported

A highly significant preference for the contralateral (“impaired”) forelimb was observed at 28 days post-MCAO after MHP36 (laterality score = -0.55 ± 0.12) or MHP36 plus E 2 (-0.43 ± 0.035) , whereas complete restoration of spontaneous forelimb use symmetry to pre-MCAO baseline scores was achieved by 28 days post-MCAO after MHP36-Dax1KD grafts (-0.03 ± 0.12, n.s.) .

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