The Value of In Vivo Reflectance Confocal Microscopy as an Assessment Tool in Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study.

22 While 40% of sensory innervation in the hand is attributed to MCs, the highest density is distributed in the fingertips, with a decreasing trend proximally. 22 , 25 Substantial MC reductions occur in HIV, diabetic, and hereditary peripheral neuropathies. 22 Diminished density and sensory deficit are correlated to Parkinson’s disease severity. 26 A case study of bortezomib-induced CIPN showed a parallel decrease in ENF and MC density by skin

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Despite the predominance of small fiber dysfunction, there is suggestion of large fiber impairment based on an increasing trend in MDT over time ( Supplementary Fig.

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