Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion.

There was a highly significant difference in the ratio of read counts in CDC animals compared to the read count ratio for the two alternative haplotypes in the CDF cows (lsmean 0.0104, se 0.134, for CDC vs. lsmean 1.5498, se 0.069, for CDF, p = 1.583 e −10 , Fig. 5 B).

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