BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults.

At 5.5 months after primary vaccination, the neutralizing activity correlated weakly with IgM/G titers; however, after the ‘booster’ (7 months after primary vaccination), the correlation was highly significant for all variants, indicating that induction of high titers is associated with potent neutralization ( Figure 2D , r ≥ 0.73, Spearman).

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