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Non-Invasive Skin Imaging Assessment of Human Stress During Head-Down Bed Rest Using a Portable Handheld Two-Photon Microscope.

Front Physiol · 2022 · PMC9358145 · PMID 35957987

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an increasing trendno p-value reported
The results showed that the SAAID has an increasing trend after 15 days of head-down bed rest ( Figures 5A–C ).

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a decreasing trendno p-value reported
The TPEF showed a decreasing trend thereafter but did not return to the original level at 15 days of bed rest.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.