Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis.

EMBO Mol Med · 2022 · PMC9358397 · PMID 35785521

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highly significantno p-value reported

Notably, upregulation of IL‐6 and IL‐1 signaling pathways, which are essential cytokines contributing to the senescence‐associated secretory phenotype (SASP; He & Sharpless, 2017 ), conspicuously overlapped within irradiated epidermal and dermal clusters that also displayed highly significant upregulation in Senescence Pathways (Table EV1 ).

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